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DOI: 10.1038/385165a0 Melanocortin Receptor Selectivity Profiling Comparative receptor binding studies have systematically characterised MT-2s binding affinities across MC1RMC5R relative to native -MSH, NDP--MSH, MT-1, and Bremelanotide establishing it as the reference broad-spectrum melanocortin agonist for multi-receptor pathway studies and the benchmark compound in melanocortin analogue SAR research

We observed a pronounced vehicle-corrected weight loss of 15.2% in the group treated with GLP-1MK-801 compared with 3.5% in the group treated with the parent GLP-1 analogue after 9 days of treatment, underscoring that the weight-lowering efficacy of the conjugate is intact in the absence of functional MC4R signalling (Fig

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