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We learned from previous work conducted in our laboratory that the N-terminus of the molecule is critical for binding and activity [96-98]

Joint and Connective Tissue Support: Ideal for chronic overuse injuries and degenerative conditions

[DOI: 10.1136/bmj.c365] [DOI] [PubMed] [Google Scholar] Lam 2013 Lam JR, Schneider JL, Zhao W, Corley DA

The one or more hepatocyte growth factor mimics has or have a general structural formula R r R 2 -R 3 -NH-(CH 2 ) n -C-NH 2 1 2 3 where Rj is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine