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This pain, characterized by originating from regions with abnormal sensation, may present as pain in the absence of stimuli, pain from normally nonpainful stimuli (allodynia), or disproportionate pain in response to harmful stimuli (hyperalgesia)

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PMID: 111 LiburkinDanTToledanoSNeufeldG

13 However, while these approaches can provide benefit in the treatment of indications, there are limitations: fasting is often required before and after drug administration (such as with the GLP-1 receptor agonist Rybelsus, 14 which contains salcaprozate sodium (SNAC) as the PE) and some have raised safety concerns due to the potential for irreversible intestinal epithelium damage