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2.2 Lipid metabolism A comprehensive network of lipid metabolic pathways, including fatty acid synthesis, uptake, -oxidation, phospholipid synthesis/remodeling, and lipid storage/release, interfaces with the cellular antioxidant defense machinery, thereby influencing the cells vulnerability to ferroptosis ( ACSL4 enzymatically activates long-chain PUFAs, such as arachidonic acid (AA) and adrenic acid (AdA), by conjugating them with coenzyme A (CoA) to form PUFA-CoA derivatives ( The hypothalamus acts as an integrative center for systemic metabolism, modulating lipid levels through multiple pathways
Commercial Availability: In the U.S., after FDA approval for women, Vyleesi was marketed by AMAG Pharmaceuticals initially, then rights were transferred
doi: 10.1016/S0140-6736(22)01439-8 3 MatthayMAZemansRLZimmermanGAArabiYMBeitlerJRMercatAet al
