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203 In contrast, adding 200 mg diazoxide per kg to 5 mg/kg tamoxifen synergistically prolonged the remission duration and decreased tumor weight, although the latter effect was lost at the higher dose of 50 mg/kg tamoxifen (Table 3)

This indicates that -arrestins act primarily as inhibitory on GLP-1R cAMP signaling during chronic agonist exposure, rather than being essential for receptor internalization [53]

GLP-1 receptor signaling in the laterodorsal tegmental nucleus attenuates cocaine seeking by activating GABAergic circuits that project to the VTA