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The most common genetic models include several MRL mouse variants for autoimmune thyroiditis, arthritis and lupus, several variants of New Zealand Brown mice (NZB), New Zealand White mice (NZW) and BXSB mice for lupus, and the non-obese diabetic (NOD) mouse and BioBreeding (BB) rat for insulin-dependent diabetes mellitus (Cohen & Miller, 1994)
The truth is, aging skin isnt just about time
Subsequent debate regarding assay specificity, circulating concentrations, and translational relevance led to skepticism regarding irisins role in humans
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