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These limitations may partially explain the discrepancy between promising preclinical results and the limited success observed in clinical trials

Overload of mitochondria with ammonium instigates over-production of reactive oxygen species and opening of mitochondrial permeability transition pore, which further damages astrocytes and induce astrocyte swelling

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 25% of the global population [1] , and 20-30% of these cases progress to a more severe stage known as MASH [2]

Besides halogen ions, FA + and Cs + are more capable to suppress cation migration