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However, in cases of severe hepatic injury in which hepatocyte proliferation is inhibited, cells of biliary ductular origin (specifically, terminal bile ductules called the canals of Hering) can give rise to bipotent progenitor cells (known as oval cells), which differentiate into hepatocytes restoring liver regeneration.21, 22 A dose- and time-dependent biphasic oval cell or HPC reaction, largely restricted to the smallest portal tracts, has also been reported after the administration of sublethal doses of APAP in mice