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Claudins are the principal pore-forming components and determine ion selectivity and paracellular permeability based on isoform expression and junctional organization

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Signs of CCD may include the following (not all dogs will exhibit all of these symptoms): Confusion or disorientation Not recognizing (or becoming startled by) familiar people or places Forgetfulness, including inability to remember tricks previously learned Wandering through the house Not responding to name being called Staring into space or at walls, getting lost in corners Problems with learning Lack of awareness of surroundings Having accidents in the house Decreased attention Less interest in play Whining and barking for no apparent reason Pacing, restlessness, walking in circles Excessive panting Lack of interest in food (some dogs may even forget to eat) Changes in sleep/wake cycles (sleeping all day and wandering through the house at night) Withdrawing from interactions with family members Anxiety or irritability Uncharacteristic aggression towards people or other pets in the household Personality changes Diagnosing Canine Cognitive Dysfunction Diagnosis of CCD is a diagnosis of exclusion, which means that other causes are ruled out first through process of elimination