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The study quantified cytokines, neurotransmitters, oxidative stress markers and detoxification enzymes using ELISA-based assays, revealing that VPA exposure disrupted glutathione balance, increased IL-6, CYP450 and glutamate, and reduced serotonin and IFN-, while curcumin partially restored these alterations ( Furthermore, Yang and Bhandari employed a PPA-induced rat model of autism, using male-only Sprague-Dawley rats that received intracerebroventricular infusions of 1M PPA
Notably, miR-4443 has been implicated in tumorigenesis, metastasis, and chemotherapy resistance, underscoring its dual role in cancer progression [103]
Chen M, Yi L, Zhang Y, Zhou X, Ran L et al (2016) Resveratrol attenuates trimethylamine-N-oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota
However, this does not mean patients and healthcare professionals should dismiss all considerations when combining these treatments
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