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In some embodiments, local otic delivery of the auris formulations or compositions described herein allows for controlled release of active agents to auris structures and overcomes the drawbacks associated with systemic administration (e.g., low bioavailability of the drug in the endolymph or perilymph, variability in concentration of the drug in the external, middle and/or internal ear)

At that time, the animals were sacrificed to extract lung, liver, spleen and brain, and to determine the bacterial load from homogenates obtained from each organ

In other embodiments, the pharmaceutical formulations or compositions also contain other therapeutic substances

Widely recognized as one of the bodys primary intracellular antioxidants, glutathione plays a critical role in cellular redox regulation, oxidative stress response mechanisms, detoxification pathways, and maintenance of biochemical homeostasis