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Renal function: Dehydration secondary to gastrointestinal side effects can impair renal function, particularly in those with pre-existing kidney disease

Lower-Risk Profile Compared to Direct GH Because sermorelin works through the body's own feedback system, the risk of pushing GH or IGF-1 too high is built-in lower than with direct recombinant GH injections

Periods at higher concentration for intensive improvement alternate with lower-concentration maintenance phases

The results were clear: mazdutide 6 mg produced greater weight loss (10.29% vs 6.00%) and better glycemic control (HbA1c reduction of 2.03% vs 1.84%) than semaglutide 1 mg over 32 weeks