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Superoxide dismutase mimetics have been shown to be effective in the treatment of currently incurable castration-resistant prostate cancer in which the expression of superoxide dismutase-2 is severely suppressed

Despite the absence of efficacy on clinical endpoints, the trials reported biomarker changes consistent with semaglutides hypothesised biological effects

Consistently, GGCT knockdown reduced mitochondrial respiratory capacity (basal, maxillary and reserve respiration) in C4-2 cells compared with the control group (Fig

Previous studies have reported improvements in cognitive deficits with antipsychotic drugs and plant extracts (7, 21, 37, 71)