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Dietary modifications, such as adopting a fibre-rich diet, can help regulate bile acids and bilirubin levels, reducing the risk of supersaturation and precipitation

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[18] Where: T MB =bulk melting temperature c=materials constant d=particle diameter Equation 3 indicates that melting point depression is less pronounced in covalent nanoparticles due to the quadratic nature of particle size dependence in the melting Equation