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GLP-1 RAs are generally more effective in thrombotic events

Oral GLP-1 formulations represent the fastest-growing drug class segment at 34.2% CAGR through 2035

Although Lys, Asp, and Glu appear with great frequency in natural protein sequences [41], the lactamization between specific residues can be achieved by incorporating amino acids with different protecting groups in SPPS, the deprotection of these amino acids can programmatically proceed under different chemical conditions [41, 102]

Activation of the NLRP3 inflammasome in macrophages leads to the cleavage of pro-IL-1 and pro-IL-18 into their active forms, IL-1 and IL-18, which are potent drivers of inflammation (53)