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Therefore, adequate selenium supplementation may reduce oxidative stress by restoring antioxidant enzymes, reducing cell death and clotting pathways, and protecting endothelial cells, thus having an overall protective effect on the lungs and other organs to mitigate the impact of COVID-19 on the body [30]

The technology rapidly progressed with several types of co-agonists forging ahead in clinical trials including GIP/GLP-1 receptor dual agonists with one of the most notable being tirzepatide [8,9]

Updated practical management recommendations, with a specific focus on infantile-onset (Wolman) disease, have since been published by a Spanish expert panel, providing diagnostic algorithms for both phenotypes and updated treatment guidance (54)