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However, patients should distribute fluid intake throughout the day rather than consuming large volumes at once, and consider reducing intake 23 hours before bedtime to minimize nocturia

Bowel and bile duct blockage, both painful and dangerous conditions where the flow of food in the intestines is blocked, sometimes requiring emergency surgery

Design In the obesity trial, 338 participants (mean age 48 years, 48% women, mean BMI 37.3 kg/m 2 ) were randomised (2:1:1:1:1:2:2) to retatrutide 1 mg, 4 mg (titration), 4 mg (no titration), 8 mg (slow titration), 8 mg (fast titration), 12 mg or placebo over 48 weeks [45]