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It acts as a dual agonist at amylin receptors (AMY1R, AMY2R, AMY3R, formed by calcitonin receptor heterodimerized with RAMP1-3) and calcitonin receptors, with structural modifications (e.g., N-terminal fatty acid acylation, proline substitutions) preventing fibril formation, enhancing stability, and enabling once-weekly dosing via albumin binding for prolonged circulation

10.1016/j.molmed.2023.07.002 359 ParkS.-H.LeeJ

When GHK-Cu combines with hyaluronic acid, collagen IV shows a remarkable 25.4-fold increase, demonstrating synergistic effects with other skin-supporting compounds