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Key finding: First mitochondrial-derived peptide with demonstrated metabolic regulatory function

This review synthesized evidences on interactions of GST genes on outdoor air pollution and airway diseases

Specifically, HC induced a significant change in 15 proteins (i.e., 9 and 6 up- and down-regulated, respectively) involved in autophagy, including the down-regulation of NPC1 (Nieman-Pick type C) and QSOX1 (quiescin sulfhydryl oxidase 1) and the up-regulation of HMOX1 (heme oxygenase 1) and KDM4A (lysine demethylase 4A)

No other peptide of this size has been documented to have such a broad influence on human biology