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Reduced cravings and better appetite control can also alleviate the stress associated with managing food-related habits

In each case, inform patients to resume their regular once weekly dosing schedule

Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons

(1) Participants: adult patients (aged 1880 years) with the similar duration of obesity and with a newly diagnosed T2DM, pharmacologically naive, with a similar state of metabolic balance (similar HbA1c level), not achieving weight loss during previous (at least one year) non-pharmacological treatment for obesity (2) ability to give informed consent, understand and comply with the study procedures