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In a pulsed or skin cycling manner , once every 7 -10 days

28,29 Koike et al reported that treatment with vitamin C prevented cigarette smoke-induced emphysema and restored lung tissue damage in protein-30 knockout (SMP30-KO) mice characterized by accelerated aging

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Consequently, additional studies with well-characterized in vivo and in vitro models are necessary to identify direct mechanistic evidence in comparison with extrapolative evidence and define the exact mechanism of control by this axis in luteal physiology