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Within the enteric nervous system, the interstitial cells of Cajal (ICC) act as pacemakers and, accordingly, play a major role in control of gastrointestinal motor function [6, 11]

Metformin, glucose uptake and anaerobic metabolism Metformin increases gut glucose uptake and utilisation It has been known for some time that metformin increases glucose uptake and utilisation in the human intestine, resulting in an increase in lactate production in enterocytes [12, 13]