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Indeed, Gupta S et al

4 Discussion The severe insulin resistance, hepatic steatosis, dyslipidaemia and hyperphagia that characterises lipodystrophy makes effective treatment challenging and limits the effectiveness of commonly used diabetes therapies (40, 41)

In some cases, factors like hormonal imbalance, genetics, or certain medications could still cause weight gain

However, multiple mechanisms have been suggested, including the following: i) Through degradation of different cellular components, autophagy allows for the turnover of resulting substrates for energy production and protein formation, which is considered essential for the preservation of cellular bioenergetics during AKI (Jiang et al., 2012)