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To help these patients, the FDA recently approved the treatment with topical ruxolitinib, a new JAK used orally for the treatment of myelofibrosis [6] and hematological tumors [7], but when applied topically leads to the re-pigmentation of previously blanched patches [8]

The depletion of GSH inactivates GPX4, which then fails to clear lipid hydroperoxides generated from the oxidation of PUFAs in cell membranes, thereby exacerbating lipid peroxidation cascades

None of this means that Mounjaro doesnt work for women with PCOS