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In laboratory research, it is mainly studied for its ability to upregulate BDNF in the hippocampus, modulate dopaminergic and serotonergic pathways, and provide neuroprotection in ischemic injury models

Physiological Role of Folate in the Methionine Cycle Methyl Group Donation for Homocysteine Remethylation Folate provides 5-methyltetrahydrofolate (5-MTHF), a critical methyl donor in the methionine cycle

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Ethics declarations Conflict of interest All authors (Jos Pablo Miramontes-Gonzlez, lvaro Rodrigo-Alaz, Miriam Gabella-Martn, David Gonzlez-Calle, Juana Carretero-Gmez and Luis Corral-Gudino) have nothing to disclose