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When supplemented in combination with methimazole, berberine significantly altered the microbiota composition of patients, decreasing the abundance of the pathogenic bacteria Chryseobacterium indologenes and Enterobacter hormaechei while simultaneously increasing the content of the beneficial bacteria Lactococcus lactis ( 185 )

However, its effects on growth hormone, IGF-1, sleep, and metabolic health can create a hormonal environment that supports better testosterone function