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[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Sudini K., Diette G.B., Breysse P.N., McCormack M.C., Bull D., Biswal S., Zhai S., Brereton N., Peng R.D., Matsui E.C.A

The results of the trial were published in Annals of Internal Medicine on June 30

Long-term use may lead to: Increased risk of cardiovascular issues Liver and kidney strain Hormonal imbalances that can suppress natural testosterone production Potential emotional effects, such as increased aggression and mood swings These risks highlight the need for careful medical supervision, especially for those considering testosterone for muscle growth or bodybuilding purposes

The mechanisms related to the development of DN are unclear and probably involve a number of dynamic events occurring early and with the progression of diabetes