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What Is PT-141 and How Does It Work

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Effects: * LDL cholesterol * Triglycerides * HDL cholesterol * Stabilizes atherosclerotic plaques * Reduces inflammation in blood vessels Indications * Hypercholesterolemia * Mixed dyslipidemia * Familial hypercholesterolemia * Prevention of: * Myocardial infarction * Stroke * Cardiovascular disease Used in patients with: * Diabetes mellitus * Hypertension * Atherosclerotic cardiovascular disease Dosage Typical adult dose: * 5-40 mg once daily Common starting doses: * 10-20 mg daily * Lower doses in: * Elderly * Renal impairment * Asian patients Maximum: * 40 mg/day Pharmacokinetics * Oral administration * Long half-life (~19 hours) * Mainly hepatic action * Excreted partly unchanged in feces Adverse Effects Common * Headache * Myalgia * Abdominal pain * Nausea * Constipation Serious * Myopathy * Rhabdomyolysis * Hepatotoxicity * New-onset diabetes (rare) Monitoring Before and during therapy: * Lipid profile * liver function tests * CK level if muscle symptoms occur Contraindications * Active liver disease * Pregnancy * Breastfeeding * Severe hypersensitivity Statins are contraindicated in pregnancy because cholesterol is important for fetal development