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Semaglutide, the active compound in Ozempic and Wegovy, has demonstrated weight loss of up to 15 percent in clinical trials

While state Medicaid programs must cover nearly all Food and Drug Administration (FDA) approved drugs, a long-standing statutory exception allows states to choose whether to cover weight-loss drugs under Medicaid

The platform estimates one to two new GLP-1 drug launches per year beginning in 2026, with 39 GLP-1 medications currently in development

Verdict: Direct comparison difficult due to different trial designs, but retatrutide's advantage appears substantial even accounting for flexible vs fixed dosing