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The cryo-EM map for the oxyntomodulin bound complex enabled robust modelling and confident assignment of most of the side chain rotamers for oxyntomodulin, the G protein and the receptor TMD (Supplemental Figure 2A), with the exception of extracellular loop (ECL) 1 and intracellular loop (ICL) 3, which were not modelled

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While a key semaglutide patent is due to expire next year, only a handful of expirations are expected in the next five years, suggesting strong near-term protection