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The review characterized BPC157 as activating multiple overlapping signaling pathways, notably VEGFR2-mediated angiogenesis via the PI3K-Akt-eNOS axis, FAK-paxillin-driven fibroblast migration and adhesion, ERK1/2-mediated endothelial and muscle cell repair signaling, and GHR upregulation in fibroblast populations

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(b) MET-ENK and leu-enkephalin (LEU-ENK) in the putamen and globus pallidus

Here, using a several times higher cuprizone diet, followed by concomitant additional intragastrical administrations of huge cuprizone quantity, we clearly exaggerate and speed up the damaging process