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Asfaw points out, that metabolic piece is often overlooked, but can have a significant impact on hormonal symptoms, particularly during perimenopause

However, she cautioned: The speed and scale of weight loss raise important questions about metabolic consequences, including the theoretical risk of muscle loss, highlighting the need for nutritional support, resistance exercise and close monitoring

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By inhibiting NNMT, 5-Amino-1MQ has been observed in models to elevate NAD+, activate downstream metabolic regulators, and support pathways that encourage higher energy expenditure and reduced adiposity